Description

FISH is a technique that, in the field of genetics, makes it possible to locate the genes or sequence of DNA and RNA directly on the chromosome. In order to explore this, a special sequence is labeled with fluorescent material. To this end, The Payvand Clinical and Specialty Laboratory has been working to achieve its goals by using the newest and advanced technologies and with the support of the experts and experienced staff to set up the FISH section to make a small contribution to the diagnosis of certain diseases such as hematology (CLL, AML, ALL, MPNs, CML), and oncology (Neuroblastoma, Small-Cell Lung Cancer, Breast Cancer) to help treat patients of our country.

 

 

Test List

                                                                                                                                                                                                                                                                                                                                          

No

Analyte/Investigation

Specimen type

Container Type /Volume

Transport /maintenance

Turnaround Time (TAT)

1

ALK(2p23) for Lung Cancer

FFPE

FFPE from cancer/tumoral zone: 1pc

4-8 °c

7-10 days

2

ATM-TP53(11q22,17p13) for CLL prognosis

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

3

BCL6(3q27) for Non-Hodgkin’s lymphoma (NHL)

Preferred Specimen: Bone Marrow or Whole blood
Alternate: FFPE

EDTA lavender Cap / 3ml
FFPE from cancer/tumoral zone: 1pc

4-8 °c

5-7 days

4

BCR/ABL1(22q11,9q34) for CML

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

5

C-MET(7q31) for Lung Cancer

FFPE

FFPE from cancer/tumoral zone: 1pc

4-8 °c

7-10 days

6

c-MYC amplification (8q24,8cen) for
Breast, Cervical, Colon, Ovarian cancers,Myeloma,
non-Hodgkin’s lymphoma,Gastric-adenocarcinomas

FFPE

FFPE from cancer/tumoral zone: 1pc

4-8 °c

7-10 days

7

c-MYC Breakapart (8q24)
for Burkitt Lymphoma / ALL- L3

Preferred Specimen: Bone Marrow or Whole blood
Alternate: FFPE

EDTA lavender Cap / 3ml
FFPE from cancer/tumoral zone: 1pc

4-8 °c

5-7 days

8

DLEU-LAMP-12CEN(13q14,13q34,12cen)
for CLL prognosis

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

9

ERBB2(HER2/NEU) amplification (17q12,17cen) for Breast cancer

FFPE

FFPE from cancer/tumoral zone: 1pc

4-8 °c

7-10 days

10

FGFR1(8p11) for Myeloid and Lymphoid Neoplasms with Eosinophilia
(HES/CEL)

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

11

FGFR3/IGH t(4;14)(4p16,14q32)
 for Multiple Myeloma prognosis

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

12

FIP1L1/CHIC2/PDGFR A(4q12) for Myeloid and Lymphoid Neoplasms with Eosinophilia
(HES/CEL)

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

13

Glioma(1p36/1q25) & (19q13/19p13) Deletion for Glial Brain Tumours

FFPE

FFPE from cancer/tumoral zone: 1pc

4-8 °c

7-10 days

14

IGH /MAF/WWOX t(14;16)(14q32, 16q23)
 for Multiple Myeloma prognosis

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

15

IGH/MAFB t(14;20)(14q32,20q12)
 for Multiple Myeloma prognosis

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

16

IGK Breakapart
for Burkitt Lymphoma / ALL- L3

Preferred Specimen: Bone Marrow or Whole blood
Alternate: FFPE

EDTA lavender Cap / 3ml
FFPE from cancer/tumoral zone: 1pc

4-8 °c

5-7 days

17

IGL Breakapart
for Burkitt Lymphoma / ALL- L3

Preferred Specimen: Bone Marrow or Whole blood
Alternate: FFPE

EDTA lavender Cap / 3ml
FFPE from cancer/tumoral zone: 1pc

4-8 °c

5-7 days

18

MLL(11q23) for ALL/AML

Bone Marrow or Whole blood

EDTA lavender Cap / 3ml

*4-8 °c

5-7 days

19

N-MYC amplification(2p24.3,2cen) for Neuroblastoma

FFPE

FFPE from cancer/tumoral zone: 1pc

4-8 °c

7-10 days

20

PDGFRB(5q33) for Myeloid and Lymphoid Neoplasms with Eosinophilia
(HES/CEL)

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

21

PML/RARA t(15;17)(15q24,17q21) for AML-M3

Bone Marrow or Whole blood

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

22

RET(10q11) for Lung Cancer

FFPE

FFPE from cancer/tumoral zone: 1pc

4-8 °c

7-10 days

23

ROS1-6q22 for Lung Cancer

FFPE

FFPE from cancer/tumoral zone: 1pc

4-8 °c

7-10 days

24

t(11;14)(q13;q32) IGH/CCND1
for Mantle Cell Lymphoma  (MCL)

Whole blood/ Bone Marrow

EDTA lavender Cap / 3ml

4-8 °c

5-7 days

25

t(8;14) IgH/c-Myc
for Burkitt Lymphoma / ALL- L3

Preferred Specimen: Bone Marrow or Whole blood
Alternate:**FFPE

EDTA lavender Cap / 3ml
FFPE from cancer/tumoral zone: 1pc

4-8 °c

5-7 days

**Formalin-Fixed Paraffin-Embedded (FFPE) Block with Tumoral Involment

*Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

 

 

Images

 

 

                                                                                                                                                                                                                                                                                       

 

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